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. 2009 Jul 31;5(7):e1000586. doi: 10.1371/journal.pgen.1000586

Figure 7. Effects of CFTR status on diaphragmatic contractile function.

Figure 7

(A) Response of intact diaphragmatic muscle fibers to KCl-induced depolarization in Cftr+/+ versus Cftr −/− groups, under basal conditions (N = 6–7 mice per group) or with CFTR- inh172 (N = 4–5 mice per group) added to the perfusate (100 µM). (B,C): Effects of CFTR deficiency on relaxation and contraction times of the diaphragm during electrical stimulation (white bars: Cftr+/+; red bars: Cftr −/−). (D) Differential effects of Pseudomonas lung infection on diaphragmatic force capacity in Cftr+/+ and Cftr −/− mice (N = 5 mice per group). * p<0.05 for Cftr+/+ versus Cftr −/−.