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125I-Botulinum toxin (5 ng) was administered to control mice (hatched bars) or to experimental mice that had been pretreated (60 min) with anti-light chain antiserum (10 μl; dark bars). Twenty minutes after toxin challenge (n=5 animals per group), mice were sacrificed and livers and spleens were excised. The results indicated that anti-light chain antiserum promoted accumulation of toxin in both organs.
