Table 1.

The Series of Chemical Compounds Under Investigation

Skeleton I
Compound	R	R1	R2	R3	R4	R5	X	Activity, (IC50µ M)
1	H	Me	H	-	-	-	-	8.1
2	H	H	Me	-	-	-	-	0.10
3	H	Cl	H	-	-	-	-	0.55
4	H	H	Cl	-	-	-	-	0.0099
5	H	NO2	H	-	-	-	-	3.0
6	H	H	NO2	-	-	-	-	0.028
7	H	H	O-Me	-	-	-	-	0.35
8	H	NH2	H	-	-	-	-	3.8
9	H	H	F	-	-	-	-	0.087
10	H	Cl	Cl	-	-	-	-	0.47
11	H	O-Me	O-Me	-	-	-	-	5.2
12	CH2-Ph	Me	H	-	-	-	-	3.7
13	CH2-Ph	H	Me	-	-	-	-	0.75
14	CH2-Ph	H	Cl	-	-	-	-	0.17
15	CH2-Ph	NO2	H	-	-	-	-	1.6
16	CH2-Ph	H	NO2	-	-	-	-	4.8
17	C7H15	Me	H	-	-	-	-	0.39
18	C7H15	H	Me	-	-	-	-	0.13
19	C7H15	H	Cl	-	-	-	-	0.013
20	C7H15	H	NO2	-	-	-	-	0.29
21	C7H15	H	O-Me	-	-	-	-	0.46
22	C7H15	H	F	-	-	-	-	0.045
23	H	H	H	-	-	-	-	0.25
Skeleton II
Compound	R	R1	R2	R3	R4	R5	X	Activity, (IC50μ M)
24	H	H	H	H	H	H	-	0.68
25	H	NO2	H	H	H	H	-	>100
26	H	NO2	H	H	H	H	-	5.9
27	H	H	NO2	H	H	H	-	67.5
28	H	H	NH2	H	H	H	-	29
29	H	H	Cl	H	H	H	-	6.5
30	H	H	F	H	H	H	-	1.2
31	H	H	H	O-Me	H	H	-	1.6
32	H	H	H	H	O-Me	H	-	6.5
33	H	H	H	H	H	O-Me	-	4.3
34	H	H	H	Me	H	H	-	3.9
35	H	H	H	H	H	Me	-	4.6
36	H	H	H	H	F	H	-	0.43
37	H	H	H	H	Cl	H	-	5.4
38	CH2-Ph	H	H	H	H	H	-	7.1
39	Me	H	H	H	H	H	-	1.3
40	C7H15	H	H	H	H	H	-	4.3
Skeleton III
Compound	R	R1	R2	R3	R4	R5	X	Activity, (IC50µ M)
41	-	-	-	-	-	-	CH2-CH2	2.98
42	-	-	-	-	-	-	OCH2	245
43	-	-	-	-	-	-	SCH2	18.58
44	-	-	-	-	-	-	-	11.48