Table 4.

Table 4a Region of Interest Analysis: Group Mean and SD of metabolites and GM
Group	Region	% GM in ROI Mean (SD)	NAA Mean (SD)	Cr Mean (SD)	Cho Mean (SD)	NAA/Cr Mean (SD)	NAA/Cho Mean (SD)
Controls	Mixed GM + WM for Lesion	39.49 (13.17)	1.68 (0.18)	0.82 (0.05)	0.21 (0.03)	2.09 (0.22)	8.76 (1.66)
	Mixed GM + WM for Perilesion	38.45 (12.75)	1.67 (0.16)	0.78 (0.06)	0.22 (0.04)	2.22 (0.16)	8.59 (1.99)
Patients	Lesion	39.85 (15.49)	1.51 (0.28)	0.74 (0.19)	0.20 (0.07)	2.11 (0.41)	8.24 (2.45)
	Perilesion	34.24 (12.19)	1.52 (0.32)	0.74 (0.19)	0.21 (0.07)	2.12 (0.54)	8.82 (5.11)

Table 4b ROI: Significant Metabolical Abnormalities Found in Individual Patients
Patient No	Radiological classification	Metabolic Abnormality
		Malformation	Perilesional zone
1	heterotopia, polymicrogyria	NAA ↓, NAA/Cr ↓	no
2	cortical dysplasia	no	NAA/Cr ↓
3	heterotopia, polymicrogyria	no	no
4	R F transmantle dysplasia	NAA ↓	no
	L P transmantle dysplasia	na	no
	R P transmantle dysplasia	na	no
5	heterotopia, polymicrogyria	no	NAA ↓
6	polymicrogyria	no	no
7	cortical dysplasia	Cho ↑	no
8	heterotopia, polymicrogyria	no	no

Mixed GM + WM: Voxels in controls were selected to match lobe and tissue composition of the malformation and perilesional region of each patient

There were no differences between the groups. NAA lesion showed a tendency to be lower (p = 0.06)

significant; 2 SD below or above mean in corresponding regions (lobe and matched for tissue composition) of controls

no within control range; na not available