TABLE 3.
Down-regulated genes in cerebral cavernous malformations compared with arteriovenous malformations and healthy superficial temporal arteries
| Classification | Accession no. | Fold change | Description |
|---|---|---|---|
| Apoptosis | U83981 | 2.5 | Protein phosphatase 1, regulatory (inhibitor) subunit 15A |
| Z35491 | 1.4 | BCL2 associated athanogene-1 glucocorticoid receptor-associated protein | |
| Cellular components | D17408 | 22.8 | Calponin 1, basic smooth muscle |
| M63391 | 15.2 | Desmin | |
| J00068 | 8.7 | Adult skeletal muscle α-actin | |
| L38486 | 4.6 | Microfibril-associated glycoprotein 4 | |
| M77016 | 4.6 | Tropomodulin tropomyosin binding protein | |
| AI888563 | 3.6 | Smoothelin | |
| M95787 | 2.9 | Transgelin 22-kDa smooth muscle protein | |
| AL050396 | 2.3 | Filamin A endothelial actin binding protein | |
| X13839 | 2.2 | Vascular smooth muscle α-actin | |
| Enzyme | J03779 | 1.9 | Membrane metalloendopeptidase (MME) |
| U43195 | 1.8 | ρ-associated, coiled-coil containing protein kinase (ROCK1) | |
| AL049415 | 1.5 | Disintegrin and metalloproteinase 19 (meltrin β) | |
| AF038203 | 1.4 | LIS1-interacting protein NUDEL, endooligopeptidase A | |
| AF045458 | 1.4 | Serine/threonine kinase (ULK1) | |
| Heat shock protein | Z23090 | 2.0 | Heat shock 27-kDa protein 1 |
| M16660 | 1.3 | Heat shock 90-kDa protein 1, β | |
| Myosin | D10667 | 87.0 | Smooth muscle myosin heavy chain |
| AF013570 | 20.4 | Smooth muscle myosin heavy chain SM2 | |
| AF001548 | 17.8 | Myosin heavy chain (MHY11) | |
| M12125 | 6.7 | Fibroblast muscle-type tropomyosin | |
| J02854 | 5.6 | Myosin light chain (MYL9) | |
| M22919 | 2.2 | Nonmuscle/smooth muscle alkali myosin light chain | |
| Miscellaneous | U49957 | 3.3 | LIM protein (LPP) |
| M96789 | 3.1 | Connexin 37 gap junction protein (GJA4) | |
| U66579 | 2.7 | G protein-coupled receptor-20 | |
| M35999 | 2.5 | Integrin β chain platelet glycoprotein IIIa | |
| X67055 | 2.5 | Inter-α-trypsin inhibitor heavy chain H3 | |
| AF035119 | 1.8 | Deleted in liver cancer-1 (DLC1) | |
| AF032886 | 1.8 | Forkhead protein (FOXO3A) | |
| M88279 | 1.3 | Immunophilin (FKBP4) binding protein | |
| U25789 | 1.3 | Ribosomal protein L21 | |
| Unknown | AB011099 | 9.5 | KIAA0527 large protein from brain |
| AB023139 | 4.4 | KIAA0922 large protein from brain | |
| AB028999 | 1.5 | KIAA1076 large protein from brain |