Table 1.
Parameter | Subj 1 | Subj 2 | Subj 3 | Subj 4 | Subj 5 | Subj 6 | Subj 7 | Subj 8 |
---|---|---|---|---|---|---|---|---|
Age | 39 | 57 | 63 | 61 | 64 | 51 | 57 | 39 |
Sex/race | M/C | M/C | M/C | M/C | M/C | M/C | M/C | M/C |
LVEF BSL→EOS | 17→32 | 26→15 | 18→37 | 31→53 | 8→51 | 35→51 | 25→50 | 19→48 |
Chip scaling factor | High/high | Low/low | Low/low | Low/high | Low/low | Low/high | High/high | Low/low |
Rx | Carv | Pbo | Met | Carv | Pbo | Met | Carv | Carv |
Peak VO2 (ml/kg/min) | 20 | 19 | 18 | 15 | N/A | 14 | 16 | 20 |
NYHA | III | II | II | III | IV | III | II | III |
Cl (l/min/m2) | 2.2 | 2.5 | 1.2 | 2.9 | 2.4 | 1.8 | 1.4 | 2.9 |
BSL, baseline; EOS, end-of study; Pbo, placebo; Met, metoprolol; Carv, carvedilol; NYHA, New York Heart Association classification.