Table 7.
Genes Exhibiting Changed Expression by Method B Criteria*
| Gene category | Increased expression (n), gene | Decreased expression (n), gene |
|---|---|---|
| Metabolic | (5); alcohol dehydrogenase β1 subunit, NAD+-specific isocitrate dehydrogenase β subunit, nuclear- encoded mitochondrial cytochrome c oxidase Va subunit, long-chain acyl-CoA synthetase, pyruvate dehydrogenase kinase isoenzyme 2 (PDK2) | (1); apolipoprotein A1 |
| Contractile protein | (1); α-myosin heavy chain | (2); skeletal tropomyosin, skeletal troponin T1 |
| Cytoskeletal | (3); β2 tubulin, actin depolymerizing factor, plakophilin 2a | (5); non-erythroid α-spectrin, microtubulin associated protein 4, nebulin, plectin, β2 spectrin |
| Extracellular matrix | (0) | (2); α2 collagen Type 1, thrombospondin-4 |
| Transcription/translation | (3); 18S rRNA, ribosomal protein L3, activator 1 | (3); helicase-like protein (DDX13), centromere protein A, forkhead protein (FREAC-1) |
| Ca2+ handling | (0) | (0) |
| Signaling/signal transduction | (2); β1-adrenergic receptor, Ser-Thr protein kinase VRK1 | (12); neuronal pentraxin receptor, frizzled-1, fibrousheathin 1, dual specificity phosphatase (MKP-5), Arg/Abl-interacting protein, protein tyrosine phosphatase, neogenin, phospholipase A2 RASF-A, calcineurin B, ras associated with diabetes (RAD), phosphatase 2A catalytic subunit-α, diacylglycerol kinase γ |
| Cell homeostasis | (2); phosphatidyl serine synthase-1, calmegin | (3); inwardly rectifying K+ channel, Na+, K+-ATPase subunit α2, amphiphysin II |
| Growth factors | (1); transforming growth factor-beta stimulated clone-22 | (4); metastasis-associated-1, insulin-like growth factor binding protein 5, insulin-like growth factor II, insulin-like growth factor binding protein-2 |
| Cell cycle/apoptosis | (1); galectin-3 | (0) |
| Immunologic/hematologic | (2); HLA-DR antigen α-chain, MHC class II lymphocyte antigen | (1); interferon regulatory factor-2 |
| Unclassified | (3); TNF-α induced protein 8, acetolactate synthase, prion protein | (4); periplakin, AF1q, immunoglobulin super family four, autoimmunogenic cancer/testis antigen NY-ESO-1 |
| Unknown function | (6) | (22) |
*
Filtered by requirement of opposite change in the patient with LVEF decline (changes in gene expression “likely related” to LVEF change).