Boxshade plot of the amino acid sequences of BMPER orthologs in vertebrates (Mus musculus [12,42], Homo sapiens [14], Pan troglodytes, Canis familiaris, Gallus gallus [13], Danio rerio, Fugu rubripes, and in Drosophila melanogaster [15]. Black boxes indicate identical amino acids, grey boxes indicate similar amino acids. Solid lines identify vWC domains 1–5, the dotted line denotes the vWD domain and the dashed line indicates the trypsin inhibitor domain (TI). BMPER orthologs share a high degree of homology in vertebrates. The TI domain is absent in Drosophila.