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. Author manuscript; available in PMC: 2009 Jul 13.
Published in final edited form as: J Mol Cell Cardiol. 2007 May 18;43(3):243–253. doi: 10.1016/j.yjmcc.2007.05.008

Figure 5. Loss of zbmper results in disturbed blood circulation and loss of blood cells.

Figure 5

(A) High magnification of a lateral view of the ventral part of the trunk of a control zebrafish. Anterior to the left. (nc) notochord, (ca) caudal aorta. Note the normal number of circulating blood cells in the dorsal aorta. (B) Lateral view of the trunk of a mildly dorsalized mutant embryo (48 hpf). Note the packed mass of circulating cells within the dorsal aorta. In live fish, this cell mass moves slightly back and forth in the rhythm of the beating heart, suggesting an obstructed outflow from the dorsal aorta. (C) In a more severe phenotype (36 hpf) only a few circulating blood cells (bc) can be observed in the same area of the dorsal aorta. (D) Cranial view of a control embryo at 72 hpf. Note the blood cells in the sinus venosus. (E) Cranial view of the same embryo as in Figure 4D (72 hpf) displaying a strong loss of blood cells in zbmper morphants. Note only few blood cells in the sinus venosus.