Table 5.
LOD scores suggestive of linkage (LOD ≥1.8) using two modeling strategies for gene-by-diabetes interaction–specific multipoint quantitative trait linkage analyses of ranked UACR in phase IV participants of the SHFS (2001 through 2003)a
| Center (Modelb) | Chromosome | Location (cM) | Chromosomal Region | Nearest Marker | 1-LOD Drop Support Interval | LOD Score |
|---|---|---|---|---|---|---|
| All centers (model 2) | 1 | 155 | 1q21.1 | D1S498 | 151 to 166 | 1.8 |
| Dakotas (model 1) | 2 | 153 | 2q23.3 | D2S151 | 144 to 172 | 1.9 |
| All centers (model 2) | 3 | 46 to 62 | 3p22.2 to 3p24.3 | D3S1277, D3S3659 | 34 to 71 | 2.6 |
| Dakotas (model 2) | 2.0 | |||||
| Dakotas (model 2) | 183 | 3q26.31 | D3S1565 | 167 to 192 | 1.8 | |
| All centers (model 1) | 6 | 86 | 6q13 | D6S460 | 62 to 104 | 2.3 |
| Oklahoma (model 1) | 2.9 | |||||
| Dakotas (models 1, 2) | 7 | 108 | 7q21.3 | D7S515 | 88 to 124 | 2.4, 2.3 |
| All centers (models 1, 2) | 151 to 168 | 7q34 to 7q36.2 | D7S661, D7S798 | 144 to 172 | 2.7, 2.0 | |
| Arizona (model 1) | 2.0 | |||||
| Dakotas (model 1) | 2.0 | |||||
| Dakotas (models 1, 2) | 9 | 99 | 9q22.31 | D9S283 | 89 to 108 | 2.2, 2.6 |
| Dakotas (model 1) | 12 | 131 | 12q24.22 | D12S86 | 119 to 138 | 2.1 |
| Dakotas (models 1, 2) | 14 | 50 | 14q21.3 | D14S276 | 46 to 85 | 2.7, 1.9 |
| All centers (model 1) | 18 | 78 | 18q21.2 to 21.3 | D18S474 | 69 to 94 | 2.2 |
| Dakotas (models 1, 2) | 3.3, 2.9 | |||||
| Dakotas (model 1) | 19 | 58 | 19q13.11 | D19S414 | 24 to 89 | 1.9 |
| Oklahoma (models 1, 2) | 20 | 49 | 20p11.21 | D20S195 | 39 to 62 | 2.1, 2.7 |
a
Linkage significance criteria were as suggested by Rao and Gu.21
b
Model 1 was adjusted for age, gender, age2, and age–gender interactions. Model 2 was additionally adjusted for diabetes status, HDL cholesterol, LDL cholesterol, TG, SBP, DBP, and smoking status.