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Inhibition of sGC by PPi and cGMP
| PPi
|
cGMP, IC50, mM
|
|||
|---|---|---|---|---|
| Enzyme state | Ki, μM | Inhibition type | αNβ | αCβ |
| Basal | 300 ± 25 | Competitive | >50 | >50 |
| YC-1 stimulated | 180 ± 20 | Competitive | 13 | >100 |
| SNP-stimulated | 175 ± 18 | Competitive | 6 | 12 |
Ki values are represented as the average (±SD) of three independent experiments for αNβ enzyme. αCβ enzymes demonstrated similar results. A total of 100 μM YC-1 or SNP was used to stimulate the enzymes.
