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. Author manuscript; available in PMC: 2010 Jul 15.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Apr 22;19(14):3783–3786. doi: 10.1016/j.bmcl.2009.04.071

Figure 2.

Figure 2

Inhibition of HIF-1α expression by 1. (a) After treating 4T1 cells under hypoxia (0.5% O2, 24 h) with and without 1, HIF-1α expression was evaluated using Western blots. By comparison with loading control (histone H1), nuclear expression of HIF-1α was significantly inhibited by 1 at concentrations higher than 10 nM. (b) In 4T1 and MDA-MB-231 cells, HIF-1α expression induced by CoCl2 (240μM, 24 h) was also inhibited by 1.