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eNOS mediates metformin-induced cardioprotection. (A) LVEDD, (B) LVESD and (C) Ejection Fraction (EF) and (D) H/BW ratios was measured at baseline and following myocardial ischemia in eNOS deficient mice ± daily metformin therapy. Values are means ± S.E.M. Numbers inside bars indicate the number of animals that were investigated in each group. *** p < 0.001 vs. Baseline, * p < 0.05 vs. Sham. Veh = vehicle, Met QD = Metformin QD.
