Table 2.
Multivariable associations of cardiovascular risk factors with high Cystatin C ≥95th percentile cut-point among all participants, in the subset without chronic kidney disease, and among participants without MA
| All Participants (n = 3,241) |
Participants without CKD (n = 2,981) |
Participants without MA (n = 2304) |
||||
|---|---|---|---|---|---|---|
| Odds Ratio (95% Confidence Interval) | p Value | Odds Ratio (95% Confidence Interval) | p Value | Odds Ratio (95% Confidence Interval) | P | |
| Age (per 10-year interval) | 3.39 (2.98-3.86) | <.0001 | 3.07 (2.66-3.53) | <.0001 | 3.20 (2.74-3.75) | <.0001 |
| Female sex | 0.65 (0.53-0.79) | <.0001 | 0.60 (0.48-0.74) | <.0001 | 0.65 (0.51-0.82) | 0.0004 |
| Hypertension treatment | 1.87 (1.54-2.27) | <.0001 | 1.54 (1.24-1.92) | 0.0001 | 1.82 (1.43-2.31) | <.0001 |
| Diastolic blood pressure (per SD change) | 0.87 (0.79-0.96) | 0.008 | 0.90 (0.81-1.00) | 0.060 | 0.94 (0.83-1.06) | 0.28 |
| BMI mg/kg2 (per SD change) | 1.56 (1.42-1.72) | <.0001 | 1.62 (1.46-1.80) | <.0001 | 1.41 (1.26-1.59) | <.0001 |
| HDL cholesterol (per SD change) | 0.68 (0.61-0.76) | <.0001 | 0.72 (0.64-0.82) | <.0001 | 0.68 (0.60-0.78) | <.0001 |
| Current smoking (yes vs no) | 2.55 (1.90-3.40) | <.0001 | 2.74 (2.02-3.72) | <.0001 | 3.08 (2.17-4.39) | <.0001 |