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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Curr Opin Immunol. 2009 Feb 14;21(1):3–9. doi: 10.1016/j.coi.2009.01.007

Figure 2.

Figure 2

A model for the Dicer-2 mediated control of FHV infection. The viral suppressor of RNAi B2 is associated with the viral RDRP, which is anchored in the outer mitochondrial membrane. B2 binds to dsRNA replicative intermediates as they are synthesized, thus protecting them from the action of Dicer-2 (left panel). When B2 is mutated, Dicer-2 binds the nascent dsRNA replication intermediates and generates massive amounts of siRNAs corresponding to the 5′ end of the genome, leading to abortive replication and protection of the infected cells (right panel).

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