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Fitness difference of V38A mutants relative to wild-type virus for periods on and off enfuvirtide therapy.
| Fitness Difference a | |||
|---|---|---|---|
| Subject | −ENF | + ENF | |
| 1 | −54% ± 6% | +498% ± 316% | |
| 2 | −35% ± 4% | +107% ± 20% | |
| 3 | First interruption | −25% ± 2% | +235% ± 85% |
| Second interruption | −65% ± 9% | n.d. | |
ENF, enfuvirtide; n.d., not done.
Fitness differences were determined following enfuvirtide interruption (−ENF) or during a four-week period of enfuvirtide “pulse” therapy (+ENF).
