Figure 3.

Spontaneous EPSCs from CA1 pyramidal neurons are unchanged in IP₃R2 KO mice. A, Representative AMPAR sEPSC traces from littermate control (n = 15) and IP₃R2 KO (n = 16) CA1 pyramidal neurons. B, AMPAR sEPSC peak amplitude (p = 0.62), 10–90% rise times (p = 0.94), decay tau (p = 0.66), and event frequency (p = 0.90) were not significantly different between littermate control and IP₃R2 KO CA1 pyramidal neurons as determined by Student's t test. C, Representative NMDAR sEPSC traces from littermate control (n = 15) and IP₃R2 KO (n = 9) CA1 pyramidal neurons. D, NMDAR sEPSC peak amplitude (p = 0.39), 10–90% rise times (p = 0.92), decay tau (p = 0.94), and event frequency (p = 0.70) were not significantly different between littermate control and IP₃R2 KO CA1 pyramidal neurons as determined by Student's t test. Error bars indicate SEM.