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. Author manuscript; available in PMC: 2009 Jul 14.
Published in final edited form as: Biochemistry. 2009 Apr 14;48(14):3068–3077. doi: 10.1021/bi900167q

Figure 2.

Figure 2

Uridine-based inhibitors of E. coli LpxC. Two compounds, 1-68A (Panel A) and 2-68A (Panel B), were identified that inhibited E. coli LpxC with apparent mid- μM IC50s. (Panel C) Analysis of concentration-response plots fitted with Eq. 1 gave IC50 values of 27 μM and 120 μM for 1-68A (black circles) and 2-68A (open squares), respectively, where H=0.7.