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LpxC inhibition by 1-68A analogs. Analogs of 1-68A containing variable substituents on the benzene ring were synthesized and tested for inhibition of E. coli LpxC. Of this series, only 1-68Aa was of comparable potency to 1-68A, and is likewise a time-dependent inhibitor of E. coli and Helicobacter pylori LpxC (data not shown).
