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. Author manuscript; available in PMC: 2009 Jul 14.
Published in final edited form as: Biochemistry. 2008 Feb 7;47(9):2814–2825. doi: 10.1021/bi702457c

Figure 2. Proposed reaction catalyzed by LpxO.

Figure 2

A) The LpxO reaction is proposed to proceed by a mechanism similar to that used by other Fe2+/O2/α-ketoglutarate dependent dioxygenases, most likely catalyzing the direct 2-hydroxylation of the 3′-myristate chain of hexa-acylated Kdo2-lipid A (38), as demonstrated in this study. B) Predicted topology and trans-membrane segments of LpxO based on the TMHMM algorithm (39).