Table 2. Analysis of the association of Aβ42 and metal levels in cerebrospinal fluid.

Statistical analysis using a general linear regression model with a log-link, adjusted for age at death, education, APOE ε4, post mortem interval until CSF collection, and time from last clinical exam until death.

Metals (μM)	Mean Aβ42 (ng/L)	Mean difference (95% CI)	p-trend
Copper (range 0.01-5.7)
Low (<0.4)	114.9	0 (reference)	<0.0001
Mid (0.4-0.75)	94.7	-0.19 (-0.62, 0.2)
High (> 0.75)	32.6	-1.26 (-1.7, -0.8)
Zinc (range 0.21-12.45)
Low (<1.3)	116.7	0 (reference)	<0.0001
Mid (1.3-2.5)	95.2	-0.2 (-0.6, 0.2)
High (> 2.5)	33.8	-1.2 (-1.7, -0.76)
Iron (range 0.53-31.7)
Low (<7.2)	118.6	0 (reference)	0.001
Mid (7.2-12.0)	70.6	-0.52 (-0.99, -0.05)
High (> 12.0)	52.2	-0.83 (-1.4, -0.34)
Manganese (range 0.32-0.52
Low (<0.16)	110.5	0 (reference)	0.003
Mid (0.16-0.24)	75.1	-0.39 (-0.9, 0.1)
High (> 0.24)	53.3	-0.73 (-1.2, -0.2)
Chromium (range 0.03-0.43)
Low (<0.157)	94.3	0 (reference)	0.01
Mid (0.157-0.23)	102	0.08 (-0.4, 0.5)
High (> 0.23)	43.8	-0.77 (-1.23, -0.3)
Selenium (range 0.04-0.92)
Low (<0.32)	84.2	0 (reference)	0.3
Mid (0.32-0.53)	89.1	0.06 (-0.4, 0.6)
High (> 0.53)	65.6	-0.25 (-0.7, 0.2)
Aluminum (range 0.008-5.78)
Low (≤ 0.008)	86.3	0 (reference)	0.5
Mid (0.0081-0.096)	58.9	-0.38 (-1.05, 0.3)
High (> 0.096)	74.4	-0.15 (-0.56, 0.37)