Table 3. Analysis of the association of pathologic hallmarks of AD and CSF metals in cerebrospinal fluid.

	Neocortex		Hippocampus
	Neuritic plaques IRR [95%CI]	Neurofibrillary tangles IRR [95%CI]	Neuritic plaques IRR [95%CI]	Neurofibrillary tangles IRR [95%CI]
Copper
Low <0.4 μM	1	1	1	1
Mid 0.4-0.75 μM	0.99 [0.5-1.9]	1.26 [0.5-3.2]	1.0 [0.5-2.1]	1.11 [0.6-1.9]
High >0.75 μM	0.95 [0.5-2.0]	2.23 [0.8-5.9]	0.85 [0.4-2.0]	1.08 [0.6-2.0]
Zinc
Low <1.3 μM	1	1	1	1
Mid 1.3-2.5 μM	0.95 [0.48-1.87]	2.09 [0.8-5.2]	1.11 [0.5-2.6]	2.16 [1.2-3.8]
High >2.5 μM	0.82 [0.39-1.74]	1.43 [0.5-4.2]	1.14 [0.5-2.8]	1.38 [0.7-2.7]