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Synthesis of 2-Arylpropionic Acids via Oxidationa
| entry | product | oxidant | yield | %ee/conf. |
|---|---|---|---|---|
| 1 | Ibuprofen | O3 | 98 | 98 (S) |
| 2. | Naproxen | KMnO4/NalO4 | 67 | >97 (S) |
| 3. | Flurbiprofen | O3 | 95 | 98 (S) |
| 4. | Fenoprofen | RuCl3/NalO4 | 91 | >99 (S) |
| 5. |  |
KMnO4/NalO4 | 93 | 91 (S) |
Enantiomers of compounds shown in Table 9 used for the syntheses
