Table 3.
Linear regression models for continuous lipid levels against increasing number of lipid-altering risk alleles, including adjustments for conventional risk factors
| Lipid risk allele count | Lipid concentration (mg/dL) | Unadjusted |
Adjusteda |
||||
|---|---|---|---|---|---|---|---|
| Per allele effect size β (95% CI) | P-value | Variability explained (%) | Per allele effect size β (95% CI) | P-value | Variability explained (%) | ||
| LDL raising | LDL levels | 5.59 (3.96, 7.22) | 4.1 × 10−11 | 7.14 | 4.85 (2.80, 6.89) | 4.4 × 10−6 | 8.51 |
| HDL lowering | Logged HDL levels | −0.026 (−0.04, −0.02) | 3.2 × 10−6 | 3.38 | −0.021 (−0.03, 0.01) | 0.001 | 20.1 |
| Triglyceride raising | Logged triglyceride levels | 0.056 (0.04, 0.08) | 4.0 × 10−8 | 4.84 | 0.047 (0.02, 0.07) | 1.5 × 10−4 | 11.4 |
aAge (years), gender, smoking status, alcohol consumption (g/day), and body mass index (kg/m2) adjusted.