Table 4.
Logistic regression odds ratios for lipid levels crossing the therapeutic intervention threshold, comparing highest risk alleles count group against the lowest, with adjustment for conventional risk factors
| Lipid measure, Intervention thresholds | Lipid risk allele count |
Lipid risk alleles as quartiles |
|||||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | Highest vs. lowest quartile (age- and sex-adjusted OR) |
Highest vs. lowest quartile (fully adjusteda) |
P-value for trend across quartiles | |||
| OR (95% CI) | P-value | OR (95% CI) | P-value | ||||
| LDL cholesterol (mg/dL) | |||||||
| Borderline high: >130 | 1.32 (1.19, 1.48) | 5.7 × 10−7 | 3.38 (2.09, 5.47) | 7.2 × 10−7 | 3.28 (1.81, 5.93) | 8.9 × 10−5 | <0.001 |
| High: >160 | 1.34 (1.18, 1.53) | 7.1 × 10−6 | 3.00 (1.67, 5.39) | 2.5 × 10−4 | 3.37 (1.64, 6.94) | 0.001 | <0.001 |
| HDL cholesterol (mg/dL) | |||||||
| Low levels: <40 | 1.14 (1.01, 1.29) | 0.04 | 2.13 (1.10, 4.12) | 0.025 | 1.41 (0.62, 3.24) | 0.416 | 0.022 |
| High levels: >60 | 0.83 (0.76, 0.91) | 7.9 × 10−5 | 0.49 (0.31, 0.76) | 0.002 | 0.55 (0.31, 0.99) | 0.045 | <0.001 |
| Triglycerides (mg/dL) | |||||||
| Borderline high: >150 | 1.36 (1.22, 1.52) | 3.8 × 10−8 | 3.50 (2.06, 5.93) | 3.3 × 10−6 | 2.77 (1.48, 5.19) | 0.001 | <0.001 |
| High: >200 | 1.35 (1.16, 1.57) | 8.2 × 10−5 | 2.98 (1.43, 6.22) | 0.004 | 2.58 (1.09, 6.09) | 0.030 | <0.001 |
aAge (years), gender, smoking status, alcohol consumption (g/day), and body mass index (kg/m2) adjusted.