Table 2.
Individual local tumor response.
| Macroscopic tumor response | Patient | Initial tumor size (% tumor of intestinal lumen) |
after 3–4 months of therapy | best response | |
|---|---|---|---|---|---|
|
Complete luminal response of the primary (group I) |
Normal mucosa (Ia) | Pat. 07 | 85% | 30% | 30% |
| Pat. 09 | 85% | 0% | 0% | ||
| death | related to metastasis | n = 1 | 0 alive | ||
| related to other causes | n = 1 | ||||
| Adenomatous tissue (Ib) | Pat. 05* | 85% | 70% | 30% | |
| Pat. 10* | R: 85%/L: 50% | R: 60%/L: | R: 60%/L: OP | ||
| Pat. 12 | 85% | 30% | 5% | ||
| Pat. 15* | 95% | 20% | 40% | ||
| 85% | |||||
| death | related to metastasis | n = 3 | 0 alive | ||
| related to other causes | n = 1 | ||||
| Relapse after therapeutic break (group II) | Initially no tumor cells at biopsy | Pat. 03 | 80% | 60% | 0% |
| Pat. 06* | 85% | 30% | 30% | ||
| Pat. 08* | 100% | 85% | 55% | ||
| Pat. 20* | 75% | 25% | 25% | ||
| death | related to metastasis | n = 1 | 3 alive | ||
| related to other causes | n = 0 | ||||
|
Partial macros-copic response of the primary (group III) |
Histologically confirmed tumor tissue | Pat. 01* | 85% | 85% | 85% |
| Pat. 02* | 90% | 85% | 70% | ||
| Pat. 04* | 85% | 80% | 80% | ||
| Pat. 11* | 85% | 75% | 75% | ||
| Pat. 13* | 100% | 85% | 85% | ||
| Pat. 14 | 60% | 40% | OP | ||
| Pat. 16* | 60% | 30% | 20% | ||
| Pat. 17* | 100% | 85% | 85% | ||
| Pat. 18* | 90% | 85% | 85% | ||
| Pat. 19* | 80% | 70% | 65% | ||
| death | related to metastasis | n = 8 | 2 alive | ||
| related to other causes | n = 0 | ||||
* incomplete = reduced amount of therapy or therapeutic break