Abstract
In vitro studies were performed to evaluate susceptibility tests with disks containing 10 micrograms of ampicillin plus 10 micrograms of sulbactam. Interpretive zone standards of less than or equal to 11 mm (resistant), 12 to 13 mm (intermediate), and greater than or equal to 14 mm (susceptible) are proposed. A nine-laboratory coordinated study was performed to establish tentative zone size limits for quality control of ampicillin-sulbactam disks. This included data with a new control strain selected to monitor performance of such combination disks.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aswapokee N., Neu H. C. A sulfone beta-lactam compound which acts as a beta-lactamase inhibitor. J Antibiot (Tokyo) 1978 Dec;31(12):1238–1244. doi: 10.7164/antibiotics.31.1238. [DOI] [PubMed] [Google Scholar]
- English A. R., Retsema J. A., Girard A. E., Lynch J. E., Barth W. E. CP-45,899, a beta-lactamase inhibitor that extends the antibacterial spectrum of beta-lactams: initial bacteriological characterization. Antimicrob Agents Chemother. 1978 Sep;14(3):414–419. doi: 10.1128/aac.14.3.414. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Foulds G., Stankewich J. P., Marshall D. C., O'Brien M. M., Hayes S. L., Weidler D. J., McMahon F. G. Pharmacokinetics of sulbactam in humans. Antimicrob Agents Chemother. 1983 May;23(5):692–699. doi: 10.1128/aac.23.5.692. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fu K. P., Neu H. C. Comparative inhibition beta-lactamases by novel beta-lactam compounds. Antimicrob Agents Chemother. 1979 Feb;15(2):171–176. doi: 10.1128/aac.15.2.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fuchs P. C., Barry A. L., Thornsberry C., Gavan T. L., Jones R. N. In vitro evaluation of Augmentin by broth microdilution and disk diffusion susceptibility testing: regression analysis, tentative interpretive criteria, and quality control limits. Antimicrob Agents Chemother. 1983 Jul;24(1):31–38. doi: 10.1128/aac.24.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gavan T. L., Jones R. N., Barry A. L., Fuchs P. C., Gerlach E. H., Matsen J. M., Reller L. B., Thornsberry C., Thrupp L. D. Quality control limits for ampicillin, carbenicillin, mezlocillin, and piperacillin disk diffusion susceptibility tests: a collaborative study. J Clin Microbiol. 1981 Jul;14(1):67–72. doi: 10.1128/jcm.14.1.67-72.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Retsema J. A., English A. R., Girard A. E. CP-45,899 in combination with penicillin or ampicillin against penicillin-resistant Staphylococcus, Haemophilus influenzae, and Bacteroides. Antimicrob Agents Chemother. 1980 Apr;17(4):615–622. doi: 10.1128/aac.17.4.615. [DOI] [PMC free article] [PubMed] [Google Scholar]
