Figure 4.

MET conductance-dependent voltage distribution and stereocilia input capacitance. (A) The normalized tip potential (V/V_Soma) changes as a function of stereocilia length for three values of tip conductance. The length-dependent, ΔV_L, and tip conductance dependent, ΔV_T, potential drops are labeled for G_T = 300 pS. The voltage drop along the stereocilia causes a reduction in the capacitance felt at the soma (B). The capacitance measured with the METs closed (G_T = 0) represents the space-clamped value. As ΔV_L increases, the input capacitance decreases, resulting in a larger error in measurement.