Fig. 1.
Brn-3a is expressed in migrating neural crest and in sensory ganglia at early embryonic stages. (A,B) Detection of Brn-3a in a subset of migrating trigeminal (A) and trunk (B) neural crest cells in E9-9.5 embryos. Brn-3a immunoreactivity is in black and localizes in the nucleus, and p75NTR is in red and localizes in the cytoplasm. (C,D) Comparison of neurofilament (C) and Brn-3a (D) expression in sensory ganglia of E10.5 embryos. While neurofilament is present in all cranial ganglia and trunk sensory ganglia, Brn-3a is only detected in trigeminal (V), vestibulococchlear (VIII) and dorsal root ganglia (DRG). Scale bars, 100 μm (A) and 50 μm (B).