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. Author manuscript; available in PMC: 2009 Jul 14.
Published in final edited form as: Development. 1999 Jul;126(13):2869–2882. doi: 10.1242/dev.126.13.2869

Fig. 6.

Fig. 6

Progressive loss of TrkB expression in mutant ganglia. (A,B) The initial expression of TrkB receptor in trigeminal ganglia is not affected by absence of Brn-3a (not shown). However, at E12.5 when the number of TrkB-immunoreactive neurons decreases in the wild-type ganglia, the number of these neurons in mutant ganglia increases. Individual TrkB neurons in mutant ganglia contains staining characteristics similar to those in wild-type ganglia. At E15.5 (C,D) the number of TrkB-immunoreactive neurons reduces dramatically and by E17.5 (E,F) none of the remaining neurons express TrkB receptor. In contrast to the progressive loss of TrkB expression in neurons, TrkB immunoreactivity in the vasculature (arrows, A–D) is not affected in mutant ganglia. Scale bar, 50 μm.