Plasma glucose (A), plasma insulin (B), and plasma C-peptide (C) concentrations in patients with chronic pancreatitis (CP) and pancreatic exocrine insufficiency (PEI) following ingestion of a liquid meal over 15 min (0–15 min) with pancreatic enzyme substitution (PES; day 1, ▪) and without PES (day 2, □). Punctuated curves (▴) represent healthy control subjects (Ctrl) given an equal liquid meal without PES. Data are mean values ± SE. Insets: AUC values. *Significant difference (p < 0.05). Reproduced with permission from Knop FK, Vilsboll T, Larsen S, et al 2007. Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution. Am J Physiol Endocrinol Metab, 292:E324–30. Copyright © 2007 American Physiological Society.