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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Exp Neurol. 2009 Jan 29;218(2):308–315. doi: 10.1016/j.expneurol.2009.01.011

Figure 4.

Figure 4

An individual’s cytochrome oxidase activity at a given age reflects their baseline activity minus an age-dependent activity decline. Activity baselines and rates of decline vary between individuals. For heuristic purposes we have shown a cytochrome oxidase activity threshold below which AD symptoms manifest. Those with high baseline activities and slow decline rates would remain above the disease threshold until a very advanced age, while those with lower baseline activities and more rapid decline rates would cross the threshold at a much younger age. CO=cytochrome oxidase.