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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Endocrinol Metab Clin North Am. 2008 Dec;37(4):811–823. doi: 10.1016/j.ecl.2008.08.005

Figure 1.

Figure 1

Hypothalamic leptin signal transduction. Leptin inhibits NPY/AGRP and stimulates POMC/CART, resulting in an increase in anorexigenic input to the paraventricular nucleus. These changes in neuropeptide expression culminate in satiety, stimulation of energy expenditure and weight loss.