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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Endocrinol Metab Clin North Am. 2008 Dec;37(4):811–823. doi: 10.1016/j.ecl.2008.08.005

Figure 2.

Figure 2

Cross-talk between insulin and leptin signaling in the hypothalamus. Insulin inhibits NPY/AGRP and induces POMC/CART through activation of IRS and PI3 kinase. Leptin activates JAK2, which interacts with insulin via IRS.