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Lung histopathology of adult Npas3-deficient mice. (A and B) Lung histopathology from WT (A) and Npas3-Het littermates (B) at 4 months (4 mo) of age (Voerhoff's elastic tissue stain). L, airway lumen; *, pleural surface; bar, 100 μm. (C) Mean linear intercepts of lungs from P1 and 4-mo mice (3 litters each): *P < 0.0001 compared with WT. Note that there were no 4-mo-old Npas3-null mice because pups rarely survived beyond 48 h.
