Figure 3.

Genome-wide LOH analysis from a single pancreatic adenocarcinoma sample. Heatmap showing regions of normal heterozygosity (red, black) or regions of LOH (yellow) as determined by SNP array analysis. Colors represent the probability that a stretch of homozygous SNPs could arise by chance as indicated in the key. Columns represent data from genomic DNA from unsorted tissue and sorted stromal and tumor (ie, neoplastic) fractions and chromosomal location is indicated to the right. The approximate locations of key tumor suppressor loci in pancreatic cancer are indicated to the right. Widespread LOH is observed specifically in the tumor fraction but not unsorted or stromal fractions.