Table 1.
Phenotypic characteristics of homozygous mutant (mri/mri) and heterozygous (mri/+) KMI rats at 10 wk of age
| Male |
Female |
|||||
| mri/+ | mri/mri | mri/+ | mri/mri | |||
| Total length (mm) | 388.4 ± 2.9 | >>> | 295.5 ± 5.2c | 353.2 ± 6.4 | >>> | 273.0 ± 4.0c |
| Head-to-anus length (mm) | 218.8 ± 3.1 | >>> | 175.9 ± 3.6c | 193.5 ± 4.4 | >>> | 156.4 ± 2.9c |
| Tail length (mm) | 169.6 ± 2.5 | >>> | 119.6 ± 2.8c | 159.7 ± 2.8 | >>> | 116.6 ± 2.2c |
| Body weight (g) | 313.4 ± 10.8 | >>> | 232.2 ± 18.7c | 204.1 ± 11.1 | >>> | 152.2 ± 9.4c |
| Retroperitoneal fat (mg/100 g BW) | 526.9 ± 73.0 | >>> | 231.7 ± 64.6c | 547.2 ± 58.1 | >>> | 246.9 ± 52.4c |
| Brain (mg/100 g BW) | 616.4 ± 16.6 | <<< | 804.3 ± 64.7c | 877.6 ± 30.9 | <<< | 1127.4 ± 49.4c |
| Heart (mg/100 g BW) | 279.6 ± 6.0 | <<< | 303.6 ± 12.7c | 320.6 ± 6.5 | <<< | 342.8 ± 15.7c |
| Lung (mg/100 g BW) | 365.5 ± 15.0 | 372.5 ± 42.7 | 450.4 ± 20.6 | 464.6 ± 41.2 | ||
| Liver (mg/100 g BW) | 2912.7 ± 121.2 | > | 2759.9 ± 119.8a | 2671.8 ± 94.5 | 2767.4 ± 145.4 | |
| Kidney (mg/100 g BW) | 708.6 ± 37.9 | <<< | 767.4 ± 14.7c | 719.2 ± 36.1 | << | 777.0 ± 34.6b |
| Pancreas (mg/100 g BW) | 347.8 ± 47.9 | 400.5 ± 77.6 | 399.3 ± 38.1 | 432.6 ± 52.0 | ||
| Spleen (mg/100 g BW) | 214.7 ± 14.8 | < | 228.5 ± 11.0a | 246.0 ± 8.2 | <<< | 268.1 ± 15.6c |
| Adrenal (mg/100 g BW) | 14.5 ± 1.1 | <<< | 18.6 ± 1.9c | 30.3 ± 2.5 | <<< | 36.1 ± 3.6c |
| Thymus (mg/100 g BW) | 145.8 ± 14.2 | 160.9 ± 23.2 | 221.3 ± 12.0 | < | 241.4 ± 20.6a | |
| Salivary gland (mg/100 g BW) | 152.5 ± 6.0 | <<< | 183.4 ± 14.6c | 174.5 ± 3.9 | <<< | 208.5 ± 9.2c |
| Thyroid gland (mg/100 g BW) | 6.68 ± 1.05 | << | 8.16 ± 1.02b | 8.63 ± 0.78 | < | 9.94 ± 1.34a |
| Pituitary (mg/100 g BW) | 2.5 ± 0.3 | <<< | 3.2 ± 0.2c | 4.3 ± 0.8 | < | 5.0 ± 0.6a |
| Ovary (mg/100 g BW) | NA | NA | 33.1 ± 1.4 | < | 38.4 ± 6.9a | |
| Uterus (mg/100 g BW) | NA | NA | 397.8 ± 164.0 | 382.6 ± 143.9 | ||
| Testis (mg/100 g BW) | 995.4 ± 31.8 | <<< | 1256.4 ± 48.6c | NA | NA | |
| Seminal vesicle (mg/100 g BW) | 99.7 ± 12.9 | << | 121.9 ± 12.2b | NA | NA | |
| Prostate (mg/100 g BW) | 82.9 ± 8.3 | < | 96.6 ± 13.5a | NA | NA | |
BW, body weight; NA, not applicable.
Values shown are mean ± SD (n = 10) except for retroperitoneal fat (n = 7).
aP < 0.05, bP < 0.01, cP < 0.001 versus value for heterozygous animals.