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. 2009 Jul 15;20(14):3436–3450. doi: 10.1091/mbc.E08-03-0325

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© 2009 by The American Society for Cell Biology

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Figure 7. — TRAF4 is a positive regulator of Nodal signaling. (A) TRAF4 enhances mesoderm induction by Xenopus nodal 2 (Xnr2) in Xenopus animal caps. Xnr2 mRNA (10 pg) was injected at the two-cell stage into the animal pole of Xenopus embryos. Animal caps were cut at stage 8, and mesoderm marker expression was scored in animal caps harvested at early gastrula, stage 10.5. (B) Treatment of animal caps with TRAF4 MOa, but not a control MO (con mo), reduces mesoderm induction by Xnr2 (5 pg). Coinjection of TRAF4 mRNA lacking the MO target sequence (d5UTR), rescues the response of animal caps to Xnr2. The y-axis shows relative expression levels and normalization was done as explained in Figure 5 legend.