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. 2009 Jul 15;20(14):3239–3250. doi: 10.1091/mbc.E08-12-1255

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© 2009 by The American Society for Cell Biology

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Figure 1. — Genetic interactions with G1 cyclin genes. (A) List of genes that have genetic interactions with G1 cyclin pairs identified from crosses with the deletion strain collection and with a collection of temperature-sensitive strains for synthetic lethal (SL/SS) interactions and with the pGAL-GST-open reading frame (ORF) overexpression collection for synthetic dosage lethal (SDL) interactions. Query genes are listed by row and genetic interactions by column. Synthetic sick interactions are shown in yellow. (B) Pie chart showing the genes that have genetic interactions (either SL/SS or SDL) with G1 cyclin pairs clustered by GO cellular role. Categories that contribute <8% of all genes are grouped as others. (C) Diagram showing one possible scenario for genetic interactions with G1 cyclin pairs. Genes that have SL/SS interaction with CLN1, CLN2 could be in a PCL1, PCL2 regulatory pathway, because quadruple deletion of CLN1, CLN2, PCL1, and PCL2 is lethal, as shown on the left. Genes downstream of PCL1, PCL2 will escape regulation when PCL1 and PCl2 are deleted; therefore, their overexpression may cause toxicity.