Figure 2.

Heat map of protein and mRNA ortholog expression in human and mouse. (A) A heat map of one-to-one orthologs showing protein expression (in red with scale shown at left below) and mRNA expression (in blue with scale shown at right below) for mouse and human placental exchange tissues. All 6970 confidently detected ortholog proteins are shown clustered into three groups; proteins observed in both species (cluster I), one species (cluster II) or in neither species (cluster III). (B) Significant enrichment for appropriate Gene Ontology annotation terms was observed for cluster I proteins. (C) The Pearson correlation (mouse versus human) for organellar localization of co-expressed ortholog proteins in cluster I. High agreement suggests conservation of function for most ortholog proteins in this cluster.