Figure 2.

Tumor spectrum in p53^+/− mice lacking CD1d-restricted NKT cells. Tumor sections were analyzed by a trained pathologist in a blinded manner, and tumors were classified into 5 basic categories based on morphologic appearance: osteosarcomas, spindle cell tumors, and other sarcomas (SCT & other sarc), carcinomas and adenocarcinomas [(adeno)carcinoma], hematopoietic, and other malignancies are shown. Data are shown for all tumor burdened mice in various p53^+/− strains, C57BL/6, Jα18^−/−, and CD1d^−/−, regardless of sex (A), and cohorts are further subdivided into both female (B) and male (C) cases.