Table 2. Correlation of Clinical and Pathological Features with Drosha and Dicer Messenger RNA (mRNA) Levels in the 111 Patients with Invasive Epithelial Ovarian Carcinoma.☆.
| Variable | Drosha mRNA Level | Dicer mRNA Level | ||||
|---|---|---|---|---|---|---|
| Low (N = 57) | High (N = 54) | P Value | Low (N = 66) | High (N = 45) | P Value | |
| Age — yr | 61.2±13.0 | 63.8±11.7 | 0.27 | 63.1±11.7 | 61.6±13.3 | 0.54 |
| Tumor stage — no. (%) | ||||||
| I or II | 2 (3.5) | 6 (11.1) | 0.15 | 1 (1.5) | 7 (15.6) | 0.007 |
| III or IV | 55 (96.5) | 48 (88.9) | 65 (98.5) | 38 (84.4) | ||
| Tumor grade — no. (%) | ||||||
| Low | 7 (12.3) | 9 (16.7) | 0.59 | 9 (13.6) | 7 (15.6) | 0.79 |
| High | 50 (87.7) | 45 (83.3) | 57 (86.4) | 38 (84.4) | ||
| Cytoreduction — no. (%) | ||||||
| Optimal | 39 (68.4) | 47 (87.0) | 0.02 | 47 (71.2) | 39 (86.7) | 0.07 |
| Suboptimal | 18 (31.6) | 7 (13.0) | 19 (28.8) | 6 (13.3) | ||
| Response to initial chemotherapy — no. (%)† | ||||||
| Sensitive | 27 (47.4) | 32 (59.3) | 0.53 | 31 (47.0) | 28 (62.2) | 0.40 |
| Resistant or refractory | 20 (35.1) | 17 (31.5) | 23 (34.8) | 14 (31.1) | ||
| Missing data | 10 (17.5) | 5 (9.3) | 12 (18.2) | 3 (6.7) | ||
☆
Plus–minus values are means ±SD.
†
P values were calculated after missing values were excluded.