Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Substituted terphenyls 4 and 5 mimic the α-helical i, i+4, and i+7 side-chain arrangement found for the F19, W23, and L26 p53 residues (dark sticks and ribbon) in the HDM2-bound conformation. A likely conformation of terphenyl 5b (light sticks) was modelled and aligned with the three p53 residue side chains (PDB # 1YCR).
