Table 1.
Tumors induced by co-expression of zebrafish smoa1 and constitutively active human AKT1
| Tumor location (cases) | Fish age (weeks) | GFP expression | Elevated phospho-AKT1 | Diagnoses |
| Trunk (4) | 3 | Yes | ND | Rhabdomyoma |
| 4 | Yes | Yes | ND | |
| 6 | Yes | ND | ND | |
| 12 | Yes | ND | Rhabdomyoma | |
| Eye (3) | 4 | Yes | ND | Ocular Melanoma |
| 12 | Yes | Yes | Astrocytoma | |
| 12 | Yes | ND | Astrocytoma | |
| Head (4) | 6 | Yes | ND | Glioblastoma |
| 6 | Yes | ND | Glioblastoma | |
| 8 | Yes | ND | ND | |
| 12 | Yes | ND | Astrocytoma | |
| Others (2) | 4 | Yes | ND | Myxoma |
| 8 | Yes | ND | Spindle cell sarcoma | |
*The tumors were found from 4 batches of injection involving 147 injected F2 fish that had survived beyond 2-week-old. Fish were observed for one and a half years, no other tumors were found in fish more than 3 months of age. ND: Not determined.