Figure 5. HtrA2^Δ1 have reduced survival under normal and stressed conditions.

(a) Male HtrA2^Δ1 flies (red) have reduced lifespan compared with wild type control (blue), which is restored with a genomic rescue construct (black) (n=75 for each genotype). (b) HtrA2^Δ1mutant flies (red) are less resistant to oxidative stress resulting from paraquat ingestion compared to wild type controls (blue) or rescued flies (black). n= 200 for each genotype. (c) HtrA2^Δ1mutant flies are more sensitive to rotenone-induced oxidative stress (red) than wild type controls (blue) or the HtrA2^Δ1 rescued line (black). n= 200 for each class. Data is presented as Kaplan-Meier survival distributions, Log-rank tests were performed to determine statistical significance. Individual p values are shown with the figure.