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. 2009 Jun 18;28(13):1831–1842. doi: 10.1038/emboj.2009.155

Figure 3.

Figure 3

NMR structure of the NH2-terminal PH domain of INPP5B. (A) Cα backbone traces of the 20 lowest-energy structures of the NH2-terminal PH domain of INPP5B in superimposition. Traces are rainbow coloured with the NH2-terminus in red and the COOH-terminus in blue. Numbers and corresponding small filled circles indicate residues multiple of 20. (B) Ribbon diagram of a representative structure from (A). (C) Structure comparison of the PH domains from OCRL (in green and red) and from INPP5B (in blue and pink). (D) Sequence alignment of the NH2-terminal PH domains of INPP5B orthologs in several species. The human OCRL PH domain sequence is alignment on the bottom line based on 3D structure. Secondary elements are drawn under the alignment. Entrez database accession numbers are as follow: INPP5B_AP, GI: 193671757; INPP5B_AM, GI: 110761623; INPP5B_HS, GI: 55666459; INPP5B_ BT, GI: 194665894; INPP5B_AA, GI: 157134484; INPP5B_ DM, 24639220; INPP5B_ SP, GI: 115947205; INPP5B_MM, GI: 30231213; OCRL_HS, GI: 13325072. AP, Acyrthosiphon pisum; AM, Apis mellifera; HS, Homo sapiens, BT, Bos Taurus; AA, Aedes aegypti; DM, Drosophila melanogaster; SP, Strongylocentrotus purpuratus; MM, Mus musculus.