Skip to main content
. 2009 Jun 18;28(13):1831–1842. doi: 10.1038/emboj.2009.155

Figure 7.

Figure 7

Model of the full-length OCRL at the membrane interface. The inositol 5-phosphatase domain together with the ASH and RhoGAP-like domains are docked at the membrane interface as proposed earlier (Erdmann et al, 2007). The NH2-terminal PH domain of OCRL is connected to the 5-phosphatase domain by a long flexible linker region. An FxDxF motif within this region mediates binding to the endocytic clathrin adaptor AP-2. The β-propeller NH2-terminal region of clathrin binds directly to OCRL through two clathrin boxes in the NH2-terminal and C-terminal region of OCRL, respectively, and indirectly through AP-2. Binding site for Rab5 and APPL1 in OCRL are also indicated.