Table 1.

Risk category as assessed by bone marrow plasma cell FISH analysis and ISS stage, and corresponding response after 4 cycles.

Risk Category	Frequency	ORR	≥VGPR
Deletion 13	50% (16/32)	94% (15/16)	63% (10/16)
Deletion 17	13% (4/31)	75% (3/4)	50% (2/4)
t(4;14)	18% (6/33)	83% (5/6)	50% (3/6)
Hyperdiploid	21% (7/33)	100% (7/7)	71% (5/7)
ISS Stage 3	30% (10/33)	80% (8/10)	60% (6/10)

Abbreviations: ORR, overall response; ≥VGPR, very good partial response or better; ISS, international staging system