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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Mol Cancer Ther. 2009 Jun 30;8(7):2015–2026. doi: 10.1158/1535-7163.MCT-08-0929

Figure 4.

Figure 4

8-oxodG-mediated cell death occurs within 24 hours of acute exposure to cisplatin and oxaliplatin and is distinct from differential effects of each drug upon cell proliferation. (a, b) viability of selected fpg and α-OGG1 clones was compared to control 16 hours after cisplatin (a) or oxaliplatin (b) treatment as measured by cell number (Hoechst fluorescence). (c) cell membrane damage-mediated lactate dehydrogenase (LDH) release into the culture media after 1 hour exposure of HEK pC 1c cells to the indicated dose of platinum compounds at 4, 12 and 24 hours post-treatment. LDH release was compared to untreated control. (d) effects of cisplatin and oxaliplatin exposure (30 uM, 1 hour) upon selected HEK clone proliferation over 6 days post-treatment (cell number determined by Hoechst fluorescence). *, **P<0.05 compared to control. α, β, γ, χ, δP<0.05 compared to control.