Figure 10.

Qualitative phase diagram showing the regimes of parameter space in which endocytosis is dominant. Diagrams a–c correspond to fast, intermediate, and slow coreceptor binding, respectively. In all diagrams, parameters falling within the blue region left of the vertical thick dashed line favor full viral wrapping before fusion occurs (P_M ≈ 1). In the yellow sector above the thin-dashed curves, the rate of endocytosis exceeds the effective rate of fusion in the fully wrapped state. In the green intersection of these regions, the virus is likely to reach the fully wrapped state and undergo endocytosis. Note that when coreceptor binding is very slow (c), the virus reaches the fully wrapped state for all values of k_f.